{"id":230,"date":"2006-06-06T16:06:40","date_gmt":"2006-06-06T20:06:40","guid":{"rendered":"http:\/\/vitamin-max.com\/word\/?p=230"},"modified":"2006-06-06T16:06:40","modified_gmt":"2006-06-06T20:06:40","slug":"%e7%a7%91%e7%a0%94%e9%9c%80%e8%a6%81%e9%92%b1%e6%9d%a5%e5%a0%86","status":"publish","type":"post","link":"https:\/\/vitamin-max.com\/word\/2006\/06\/%e7%a7%91%e7%a0%94%e9%9c%80%e8%a6%81%e9%92%b1%e6%9d%a5%e5%a0%86\/","title":{"rendered":"\u79d1\u7814\u9700\u8981\u94b1\u6765\u5806"},"content":{"rendered":"<p>\u6700\u65b0\u4e00\u671fScience\u4e0a\u53d1\u8868\u4e86\u6587\u7ae0\u300a<a href=\"http:\/\/www.sciencemag.org\/cgi\/content\/full\/312\/5778\/1355\">Metagenomic Analysis of the Human Distal Gut Microbiome<\/a>\u300b\uff0c\u6587\u7ae0\u91c7\u6837\u4e24\u4e2a\u5065\u5eb7\u4eba\u4f53\u6392\u6cc4\u7269\u5185\u7684\u7ec6\u83cc\uff0c\u8fdb\u884c\u4e86\u76f8\u5f53\u4e8eenvironmental\u73af\u5883\u6d4b\u5e8f\u7684\u7814\u7a76\u3002\u5982\u4e0b\u9762\u5f15\u7528\uff0c\u4ed6\u4eec\u4e00\u5171\u83b7\u53d6\u4e86\u63a5\u8fd1140,000(\u5341\u56db\u4e07)\u9ad8\u8d28\u91cf\u6d4b\u5e8f\u8bfb\u53d6\u7ed3\u679c\uff0c\u83b7\u53d6\u4e86\u63a5\u8fd180,000,000bp(\u516b\u5343\u4e07\u78b1\u57fa\u5bf9)\u7684\u5e8f\u5217\uff0c\u5e73\u5747\u6bcf\u4e2aread\u6709570bp\u3002\u76f8\u5f53\u4e8e\u4ec5\u4ec5\u662f\u9ad8\u8d28\u91cf\u7684\u6d4b\u5e8f\u53cd\u5e94\uff0c\u5c31\u6709\u81f3\u5c11\u5341\u56db\u4e07\u4e2a\u3002\u5982\u679c\u4e00\u6b21\u6d4b\u5e8f\u6210\u672c\u4e3a3\u7f8e\u5143\uff0c\u5355\u5c31\u6d4b\u5e8f\u53cd\u5e94\u6210\u672c\u5c31\u6709\u56db\u5341\u591a\u4e07\u7f8e\u5143\u4ee5\u4e0a\uff0c\u5982\u679c\u6709\u4e00\u534a\u7684\u53cd\u5e94\u662f\u4f4e\u8d28\u91cf\u7684\u6d4b\u5e8f\u7ed3\u679c\uff0c\u6210\u672c\u968f\u5373\u63d0\u9ad8\u4e00\u500d\u3002<\/p>\n<blockquote><p>A total of 65,059 and 74,462 high-quality sequence reads were generated from random DNA libraries created with fecal specimens of two healthy humans (subjects 7 and 8). These two subjects, ages 28 and 37, female and male, respectively, had not used antibiotics or any other medications during the year before specimen collection (11). The combined sequenced distal gut &#8220;microbiome&#8221; of subjects 7 and 8 consisted of 17,668 contigs that assembled into 14,572 scaffolds, totaling 33,753,108 bp. The scaffolds ranged in size from 1000 to 57,894 bp and the contigs from 92 to 44,747 bp. The average depth of sequence coverage in contigs was 2.13-fold. Forty percent of the reads (56,292 total) could not be assembled into contigs, most likely because of a combination of low depth of coverage and low abundance of some organisms within the specimens. Together, these singletons accounted for an additional 45,078,063 bp of DNA.<\/p><\/blockquote>\n<p>\u6587\u7ae0\u6700\u540e\u8bf4\uff0c\u9700\u8981\u8fdb\u884c\u66f4\u591a\u7684\u7814\u7a76\uff0c\u91c7\u6837\u66f4\u591a\u7684\u5fae\u751f\u7269\u79cd\u7c7b\uff0c\u4e0d\u540c\u5e74\u9f84\u3001\u996e\u98df\u3001\u75be\u75c5\u72b6\u6001\u3001\u4e0d\u540c\u73af\u5883\uff0c\u4ee5\u53ca\u95f4\u9694\u4e0d\u540c\u7684\u65f6\u95f4\u3002\u8fd9\u7247\u6587\u7ae0\u57fa\u672c\u4e0a\u4e5f\u5c31\u91c7\u4e86\u4e24\u4e2a\u6837\uff0c\u82b1\u6389\u4e86\u5f88\u591a\u94b1\u3002\u5982\u679c\u91c7\u6837\u8981\u5982\u6b64\u4e30\u5bcc\uff0c\u9700\u8981\u591a\u5c11\u94b1\u5462\uff1f\u4e0d\u8fc7\u6587\u7ae0\u8868\u793a\uff0c\u8fd9\u9879\u7814\u7a76\u5f88\u6709\u610f\u4e49\uff0c\u57fa\u672c\u4e0a\u5bf9\u4e8e\u4eba\u7c7b\u5065\u5eb7\u6709\u65b9\u65b9\u9762\u9762\u7684\u597d\u5904\uff0c\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u53ea\u8981\u548c\u4eba\u6709\u5173\u7684\u7814\u7a76\uff0c\u7ecf\u8d39\u603b\u662f\u6bd4\u8f83\u5bb9\u6613\u62ff\u7684\uff1a<\/p>\n<blockquote><p>The results should provide a broader view of human biology, including new biomarkers for defining our health; new ways for optimizing our personal nutrition; new ways for predicting the bioavailability of orally administered drugs; and new ways to forecast our individual and societal predispositions to disorders such as infections with pathogens, obesity, and misdirected or maladapted host immune responses of the gut.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>\u6700\u65b0\u4e00\u671fScience\u4e0a\u53d1\u8868\u4e86\u6587\u7ae0\u300aMetagenomic Analysis of the Human Distal Gut Microbiome\u300b\uff0c\u6587\u7ae0\u91c7\u6837\u4e24\u4e2a\u5065\u5eb7\u4eba\u4f53\u6392\u6cc4\u7269\u5185\u7684\u7ec6\u83cc\uff0c\u8fdb\u884c\u4e86\u76f8\u5f53\u4e8eenvironmental\u73af\u5883\u6d4b\u5e8f\u7684\u7814\u7a76\u3002\u5982\u4e0b\u9762\u5f15\u7528\uff0c\u4ed6\u4eec\u4e00\u5171\u83b7\u53d6\u4e86\u63a5\u8fd1140,000(\u5341\u56db\u4e07)\u9ad8\u8d28\u91cf\u6d4b\u5e8f\u8bfb\u53d6\u7ed3\u679c\uff0c\u83b7\u53d6\u4e86\u63a5\u8fd180,000,000bp(\u516b\u5343\u4e07\u78b1\u57fa\u5bf9)\u7684\u5e8f\u5217\uff0c\u5e73\u5747\u6bcf\u4e2aread\u6709570bp\u3002\u76f8\u5f53\u4e8e\u4ec5\u4ec5\u662f\u9ad8\u8d28\u91cf\u7684\u6d4b\u5e8f\u53cd\u5e94\uff0c\u5c31\u6709\u81f3\u5c11\u5341\u56db\u4e07\u4e2a\u3002\u5982\u679c\u4e00\u6b21\u6d4b\u5e8f\u6210\u672c\u4e3a3\u7f8e\u5143\uff0c\u5355\u5c31\u6d4b\u5e8f\u53cd\u5e94\u6210\u672c\u5c31\u6709\u56db\u5341\u591a\u4e07\u7f8e\u5143\u4ee5\u4e0a\uff0c\u5982\u679c\u6709\u4e00\u534a\u7684\u53cd\u5e94\u662f\u4f4e\u8d28\u91cf\u7684\u6d4b\u5e8f\u7ed3\u679c\uff0c\u6210\u672c\u968f\u5373\u63d0\u9ad8\u4e00\u500d\u3002 A total of 65,059 and 74,462 high-quality sequence reads were generated from random DNA libraries created with fecal specimens of two healthy humans (subjects 7 and 8). These two subjects, ages 28 and 37, female and male, respectively, had not used antibiotics or any other medications during&hellip; <a class=\"more-link\" href=\"https:\/\/vitamin-max.com\/word\/2006\/06\/%e7%a7%91%e7%a0%94%e9%9c%80%e8%a6%81%e9%92%b1%e6%9d%a5%e5%a0%86\/\">Continue reading <span class=\"screen-reader-text\">\u79d1\u7814\u9700\u8981\u94b1\u6765\u5806<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[2,10],"tags":[],"class_list":["post-230","post","type-post","status-publish","format-standard","hentry","category--studying-and-working","category--biological-science","entry"],"_links":{"self":[{"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/posts\/230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/comments?post=230"}],"version-history":[{"count":0,"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/posts\/230\/revisions"}],"wp:attachment":[{"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/media?parent=230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/categories?post=230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vitamin-max.com\/word\/wp-json\/wp\/v2\/tags?post=230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}